使用可吸收聚乳酸螺钉固定实验性截骨术。
Fixation of experimental osteotomies with absorbable polylactic acid screws.
作者信息
Majola A
机构信息
Department of Orthopaedics and Traumatology, University Central Hospital, Helsinki, Finland.
出版信息
Ann Chir Gynaecol. 1991;80(3):274-81.
Absorbable screws made of self-reinforced poly-L-lactic acid (SR-PLLA) and poly-DL/L-lactic acid (SR-PDLLA/PLLA) were used for fixation of cancellous bone osteotomies of the distal femur in rabbits. The initial molecular weight of PLLA was 260.000 and that of PDLLA 100.000. The follow-up times were from one week to 96 weeks. Seventy-two rabbits were operated on, 36 in the PLLA group and 36 in the PDLLA/PLLA group. After sacrifice, radiographic, micro-radiographic, histologic, histo-morphometric, and oxytetracycline-labelling studies were performed. In the PLLA group 34/36 (94%) osteotomies and in the PDLLA/PLLA group 31/36 (86%) osteotomies healed without delay or angular deformity. The present investigation shows that absorbable SR-polylactic acid screws are suitable for fixation of weight loading cancellous bone osteotomies in rabbits. Based on these promising results, a clinical study where cancellous bone fractures are fixed with SR-PLLA screws has been started.
由自增强聚-L-乳酸（SR-PLLA）和聚-DL/L-乳酸（SR-PDLLA/PLLA）制成的可吸收螺钉用于固定兔股骨远端的松质骨截骨术。PLLA的初始分子量为260,000，PDLLA的初始分子量为100,000。随访时间为1周-96周。72只兔子接受了手术，PLLA组36只，PDLLA/PLLA组36只。处死后，进行了放射学、显微放射学、组织学、组织形态计量学和土霉素标记研究。PLLA组34/36（94%）的截骨术和PDLLA/PLLA组31/36（86%）的截骨术愈合，无延迟或成角畸形。本研究表明，可吸收的SR-聚乳酸螺钉适用于固定兔负重的松质骨截骨术。基于这些有前景的结果，一项使用SR-PLLA螺钉固定松质骨骨折的临床研究已经启动。
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