Jackson Craig M
Hemosaga Diagnostics Corp, 5931 Seacrest View Rd, San Diego, CA 92121-4355, USA.
Thromb Haemost. 2007 Jul;98(1):24-35.
A brief history of the development of the contemporary model for the mechanism of prothrombin activation is presented. The focus is on the advances in understanding structure-function relationships in the molecules that comprise "prothrombinase" that occurred primarily during the 1970s. A link between the "classical theory" of hemostasis and the conceptual development of activation complexes as the activators of the precursors of coagulation proteases is developed. It is argued that advances occurred when new ideas arose that could be tested and new technologies enabled more definitive experiments to be performed.
本文介绍了凝血酶原激活机制当代模型的简要发展历程。重点关注主要在20世纪70年代出现的对构成“凝血酶原酶”分子中结构 - 功能关系理解的进展。阐述了止血“经典理论”与作为凝血蛋白酶前体激活剂的激活复合物概念发展之间的联系。有人认为，当出现可以检验的新想法且新技术使更具确定性的实验得以进行时，就会取得进展。
