动脉粥样硬化斑块的攻击：《美国病理学杂志》百年研究

Plaque attack: one hundred years of atherosclerosis in The American Journal of Pathology.

机构信息

Department of Pathology, School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA.

出版信息

Am J Pathol. 2012 Jun;180(6):2184-7. doi: 10.1016/j.ajpath.2012.04.003. Epub 2012 Apr 29.

DOI:10.1016/j.ajpath.2012.04.003

Abstract

Research articles on atherosclerosis have been well represented in The American Journal of Pathology (AJP), with more than 500 articles published since 1925. An initial focus on descriptive studies led to the proposal that atherosclerosis occurs as a response to vascular injury. With time, this view was modified by a greater understanding of the roles played by lipids and integrity of the vessel wall's constituent cells and matrix. AJP has been a major contributor to the field, publishing numerous seminal research papers and review articles on the latest advances in atherosclerosis. This Centennial Review highlights these myriad contributions.

摘要

动脉粥样硬化的研究论文在《美国病理学杂志》（AJP）中得到了很好的体现，自 1925 年以来已经发表了 500 多篇文章。最初的重点是描述性研究，导致提出动脉粥样硬化是对血管损伤的反应。随着时间的推移，这种观点被对脂质的作用以及血管壁组成细胞和基质完整性的理解所修正。AJP 是该领域的主要贡献者，发表了许多关于动脉粥样硬化最新进展的重要研究论文和综述文章。本百年综述突出了这些众多的贡献。