Suzuki Wendy A
Center for Neural Science, New York University, 4 Washington Place, New York, NY 10003, USA.
Hippocampus. 2007;17(9):842-50. doi: 10.1002/hipo.20321.
Associative learning is defined as the ability to link arbitrary stimuli or actions together in memory. The neural correlates of this fundamental form of plasticity were first described in the hippocampus during delay eye blink conditioning and have since been examined using a variety of tasks in both rats and monkeys. In monkeys, the neural correlates of associative learning have been studied using conditional motor learning tasks where animals learn to associate particular visual stimuli with particular motor responses (i.e., touch left or touch right). Similar tasks have also been used to examine learning-related plasticity in motor-related areas throughout the frontal lobe and striatum. Here, we review the patterns of learning-related activity seen in these diverse brain areas during conditional motor learning. While each of these areas exhibits strong associative learning signals, the differential patterns and time courses of these signals provides insight into the unique contribution of each area to associative learning.
联想学习被定义为在记忆中将任意刺激或动作联系在一起的能力。这种基本形式可塑性的神经关联最初是在延迟眨眼条件反射过程中于海马体中被描述的，此后已在大鼠和猴子身上使用各种任务进行了研究。在猴子身上，联想学习的神经关联已通过条件性运动学习任务进行了研究，在这些任务中，动物学会将特定视觉刺激与特定运动反应（即触摸左边或触摸右边）联系起来。类似的任务也被用于研究额叶和纹状体中与运动相关区域的学习相关可塑性。在这里，我们回顾了在条件性运动学习过程中这些不同脑区中看到的与学习相关的活动模式。虽然这些区域中的每一个都表现出强烈的联想学习信号，但这些信号的差异模式和时间进程为每个区域对联想学习的独特贡献提供了见解。
