Le Feuvre C, Metzger J P, Le Pailleur C, Baubion N, Berdah J, Heulin A, Vacheron A
Clinique cardiologique, l'hôpital Necker, Paris.
Arch Mal Coeur Vaiss. 1991 Oct;84(10):1441-5.
Myocardial ischaemia was searched for by Holter monitoring before and after coronary angioplasty with primary success in 31 patients. Control angiography was performed at 24 hours and 6 months after angioplasty. Twelve patients had signs of myocardial ischaemia before angioplasty (cumulated ischaemia: 743 minutes). The degree of coronary stenosis was 92 +/- 6% before angioplasty, 25 +/- 17% immediately after the dilatation increasing to 34 +/- 25% at the 24th hour (p less than 0.002). Despite successful angioplasty myocardial ischaemia persisted in 6 patients (cumulated ischaemia: 184 minutes) and was silent in 5 of the 6 cases. In these 6 cases, control angiography at 24 hours showed either a dissection (n = 4) or a filling defect (n = 2). The angiographic outcome of the postangioplasty stenosis and at 24 hours was the same in Group I without restenosis (25 +/- 14% versus 33 +/- 22%) as in Group II with restenosis (25 +/- 22% versus 37 +/- 30%). In Group I, the degradation of the result at 24 hours was reversible at 6 months (33 +/- 22% vs 23 +/- 14%). After angiographic success, postangioplasty ischaemia present in 20% of cases was frequently silent. No correlation was observed with restenosis at 6 months which raises the possibility of a reversible microthrombotic etiology. These results justify antiaggregant and anticoagulant therapy in the 48 hours following angioplasty.
在31例冠状动脉血管成形术取得初步成功的患者中,术前和术后均通过动态心电图监测来寻找心肌缺血情况。血管成形术后24小时和6个月时进行对照血管造影。12例患者在血管成形术前有心肌缺血迹象(累积缺血时间:743分钟)。血管成形术前冠状动脉狭窄程度为92±6%,扩张后即刻为25±17%,在第24小时增加到34±25%(p<0.002)。尽管血管成形术成功,但仍有6例患者存在心肌缺血(累积缺血时间:184分钟),其中6例中有5例为无症状性缺血。在这6例中,24小时时的对照血管造影显示有夹层(n = 4)或充盈缺损(n = 2)。无再狭窄的I组血管成形术后狭窄及24小时时的血管造影结果(25±14%对33±22%)与有再狭窄的II组相同(25±22%对37±30%)。在I组中,24小时时结果的恶化在6个月时是可逆的(33±22%对23±14%)。血管造影成功后,20%的病例存在血管成形术后缺血,且常常是无症状性的。未观察到与6个月时再狭窄的相关性,这增加了可逆性微血栓形成病因的可能性。这些结果证明在血管成形术后48小时内进行抗聚集和抗凝治疗是合理的。