Woodworth Bradford A, Wood Rachel, Baatz John E, Schlosser Rodney J
Department of Otorhinolaryngology-Head and Neck Surgery, University of Pennsylvania Health System, Philadelphia, PA 19104, USA.
Otolaryngol Head Neck Surg. 2007 Jul;137(1):34-8. doi: 10.1016/j.otohns.2007.01.025.
To measure alterations in SPA1, A2, and D gene expression in various forms of inflammatory chronic rhinosinusitis (CRS).
Sinus mucosal biopsies were performed in patients with allergic fungal rhinosinusitis (AFS), CRS with nasal polyposis, cystic fibrosis (CF), and controls. SP mRNA was measured with quantitative polymerase chain reaction.
Patients with CF (n = 4) showed significantly increased SPA1 (82-fold), SPA2 (100-fold), and SPD (47-fold) mRNA (P < 0.05) when compared with controls (n = 5). Patients with CRS with nasal polyposis (n = 5) also demonstrated elevated SPA1 (27-fold), SPA2 (13-fold), and SPD (13-fold). Patients with AFS (n = 7) had increased SPA1 (5-fold), SPA2 (9-fold), and SPD (17-fold), but were not statistically significant.
SPA1, A2, and D are upregulated in various forms of CRS, but are significantly elevated in cystic fibrosis CRS.
Understanding the role of SPs in CRS will help develop novel treatment approaches for sinonasal pathoses.
检测不同类型的慢性炎症性鼻窦炎（CRS）中SP A1、A2和D基因表达的变化。
对变应性真菌性鼻窦炎（AFS）、伴鼻息肉的CRS、囊性纤维化（CF）患者及对照组进行鼻窦黏膜活检。采用定量聚合酶链反应检测SP mRNA。
与对照组（n = 5）相比，CF患者（n = 4）的SP A1 mRNA（82倍）、SP A2 mRNA（100倍）和SP D mRNA（47倍）显著增加（P < 0.05）。伴鼻息肉的CRS患者（n = 5）的SP A1 mRNA（27倍）、SP A2 mRNA（13倍）和SP D mRNA（13倍）也升高。AFS患者（n = 7）的SP A1 mRNA（5倍）、SP A2 mRNA（9倍）和SP D mRNA（17倍）增加，但无统计学意义。
SP A1、A2和D在不同类型的CRS中均上调，但在囊性纤维化CRS中显著升高。
了解速激肽在CRS中的作用将有助于开发鼻窦疾病的新治疗方法。
