1 Department of Medicine, Division of Pulmonary, Allergy and Critical Care, and.
Am J Respir Cell Mol Biol. 2014 Nov;51(5):604-14. doi: 10.1165/rcmb.2014-0095TR.
Surfactant proteins (SP)-A and SP-D (SP-A/-D) play important roles in numerous eosinophil-dominated diseases, including asthma, allergic bronchopulmonary aspergillosis, and allergic rhinitis. In these settings, SP-A/-D have been shown to modulate eosinophil chemotaxis, inhibit eosinophil mediator release, and mediate macrophage clearance of apoptotic eosinophils. Dysregulation of SP-A/-D function in eosinophil-dominated diseases is also not uncommon. Alterations in serum SP-A/-D levels are associated with disease severity in allergic rhinitis and chronic obstructive pulmonary disease. Furthermore, oligimerization of SP-A/-D, necessary for their proper function, can be perturbed by reactive nitrogen species, which are increased in eosinophilic disease. In this review, we highlight the associations of eosinophilic lung diseases with SP-A and SP-D levels and functions.
表面活性蛋白（SP）-A 和 SP-D（SP-A/-D）在许多嗜酸性粒细胞主导的疾病中发挥重要作用，包括哮喘、变应性支气管肺曲霉病和变应性鼻炎。在这些情况下，已经表明 SP-A/-D 可以调节嗜酸性粒细胞趋化性、抑制嗜酸性粒细胞介质释放，并介导巨噬细胞清除凋亡的嗜酸性粒细胞。在嗜酸性粒细胞主导的疾病中，SP-A/-D 功能的失调也并不罕见。血清 SP-A/-D 水平的改变与变应性鼻炎和慢性阻塞性肺疾病的疾病严重程度相关。此外，SP-A/-D 的寡聚化对于其正常功能是必要的，但可被反应性氮物种破坏，而这些物质在嗜酸性粒细胞疾病中增加。在这篇综述中，我们强调了嗜酸性粒细胞性肺病与 SP-A 和 SP-D 水平和功能的关联。
