Wolf Ronald L, Detre John A
Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA.
Neurotherapeutics. 2007 Jul;4(3):346-59. doi: 10.1016/j.nurt.2007.04.005.
The two most common methods for measuring perfusion with MRI are based on dynamic susceptibility contrast (DSC) and arterial spin labeling (ASL). Although clinical experience to date is much more extensive with DSC perfusion MRI, ASL methods offer several advantages. The primary advantages are that completely noninvasive absolute cerebral blood flow (CBF) measurements are possible with relative insensitivity to permeability, and that multiple repeated measurements can be obtained to evaluate one or more interventions or to perform perfusion-based functional MRI. ASL perfusion and perfusion-based functional MRI methods have been applied in many clinical settings, including acute and chronic cerebrovascular disease, CNS neoplasms, epilepsy, aging and development, neurodegenerative disorders, and neuropsychiatric diseases. Recent technical advances have improved the sensitivity of ASL perfusion MRI, and increasing use is expected in the coming years. The present review focuses on ASL perfusion MRI and applications in clinical neuroimaging.
磁共振成像（MRI）测量灌注的两种最常用方法是基于动态对比增强（DSC）和动脉自旋标记（ASL）。尽管到目前为止，动态对比增强灌注MRI的临床经验更为丰富，但动脉自旋标记方法具有几个优点。主要优点是能够进行完全无创的绝对脑血流量（CBF）测量，对通透性相对不敏感，并且可以进行多次重复测量以评估一种或多种干预措施或进行基于灌注的功能MRI。动脉自旋标记灌注和基于灌注的功能MRI方法已应用于许多临床情况，包括急性和慢性脑血管疾病、中枢神经系统肿瘤、癫痫、衰老与发育、神经退行性疾病和神经精神疾病。最近的技术进步提高了动脉自旋标记灌注MRI的灵敏度，预计在未来几年其应用会越来越多。本综述重点关注动脉自旋标记灌注MRI及其在临床神经影像学中的应用。
