Akgun Serdar, Ozisik Kanat, Kutsal Ali, Cobanoglu Adnan
City Hospital, Department of Cardiovascular Surgery, Ankara, Turkey.
Heart Surg Forum. 2007;10(4):E320-4. doi: 10.1532/HSF98.2007105.
Atrial fibrillation (AF) is the most common arrhythmia after coronary artery bypass grafting (CABG). AF is a vexing problem that causes morbidity, prolongs hospital stay, and increases costs. Numerous factors have been suggested to play a role in the development of AF. The aim of this study was to evaluate the effect of intermittent aortic cross clamping (IACC) compared with hypothermic cardioplegic solution (HCS) in the development of postoperative AF. We evaluated data obtained from 345 patients undergoing CABG with HCS (HCS group, n = 212) and IACC (IACC group, n = 173) between April 2004 and August 2005. Diabetes mellitus was observed more often in the HCS group (P < .05), otherwise both groups had similar preoperative characteristics including sex, age, the number of distal anastomoses, left ventricle ejection fraction, history of myocardial infarction, and use of beta-blocker medication. The only statistically significant difference between the groups was higher postoperative Ca-antagonist use in the HCS group. Rates of postoperative AF, however, were significantly lower in the IACC group (21.52%) than that in the HCS group (11.05%; P < .01). Postoperative Ca-antagonist use in the HCS group and smoking in the IACC group were independent predictors of AF after CABG. The incidence of postoperative AF after CABG with IACC was reduced compared with HCS. IACC with ventricular fibrillation may exert a counteractive effect against AF.
心房颤动(AF)是冠状动脉旁路移植术(CABG)后最常见的心律失常。AF是一个棘手的问题,会导致发病、延长住院时间并增加费用。许多因素被认为在AF的发生中起作用。本研究的目的是评估间歇性主动脉阻断(IACC)与低温心脏停搏液(HCS)相比在术后AF发生中的作用。我们评估了2004年4月至2005年8月期间345例行CABG患者的数据,其中使用HCS的患者(HCS组,n = 212)和使用IACC的患者(IACC组,n = 173)。HCS组糖尿病的发生率更高(P < 0.05),否则两组术前特征相似,包括性别、年龄、远端吻合口数量、左心室射血分数、心肌梗死病史和β受体阻滞剂的使用情况。两组之间唯一具有统计学意义的差异是HCS组术后钙拮抗剂的使用更高。然而,IACC组术后AF的发生率(21.52%)显著低于HCS组(11.05%;P < 0.01)。HCS组术后钙拮抗剂的使用和IACC组的吸烟是CABG后AF的独立预测因素。与HCS相比,IACC用于CABG后术后AF的发生率降低。伴有心室颤动的IACC可能对AF发挥对抗作用。