Knyazer Boris, Abramov Dan, Bilenko N, Ganiel Amir, Ishay Yaron, Katz Amos
Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheba.
Harefuah. 2008 Apr;147(4):299-304, 375.
Atrial fibrillation (AF) remains a common problem after coronary artery bypass grafting (CABG). AF increases the risk for stroke and is associated with increased length of hospitalization and mortality.
This study aimed to determine incidence, timing and predictors of post CABG AF in a prospectively evaluated cohort of patients undergoing CABG in the Negev.
Preoperative clinical data, intraoperative, intensive care and postoperative events including AF episodes were prospectively evaluated in 156 consecutive patients undergoing CABG during a nine month period ending on July 2003.
Mean age was 64.9 years (SD = 9.7, range 41 - 84 years); 76.3% (119) were male. The in-hospital mortality was 1.2% (2 patients). The incidence of AF was 32.1% (50), with 40% of the AF episodes occurring on the second postoperative day (range 1-6 days). Univariate analyses identified the following variables as risk factors for AF: female gender, older age, ethnic origin, BMI > 30, hypertension, dyslipidemia, pre CABG nitrate, Ca blockers and furosemide treatment, left atrial diameter, renal failure and post CABG respiratory complications (p <0.05). By multivariate analysis, three variables were identified as independent predictors: BMI>30 (odds ratio 2.4; 95% CI 1.2-4.8); Sephardic Jews (OR 11.2; CI 1.0-114); enlarged left atrium (OR 4.6; CI 1.5-14.1).
Consistent with previous studies, enlarged left atrium was a predictor of post CABG AF. In addition ethnic origin (Sephardic Jews) and BMI> 30 were also found to be important predictors of post CABG AF. In comparison with other studies, we not found moderate differences in outcomes and mortality in population that underwent CABG in the Negev in comparison to studies of the world.
冠状动脉旁路移植术(CABG)后房颤(AF)仍是一个常见问题。房颤会增加中风风险,并与住院时间延长和死亡率增加相关。
本研究旨在确定在内盖夫地区接受前瞻性评估的CABG患者队列中,CABG术后房颤的发生率、发生时间及预测因素。
对2003年7月结束的9个月期间连续接受CABG的156例患者的术前临床数据、术中、重症监护及术后事件(包括房颤发作)进行前瞻性评估。
平均年龄为64.9岁(标准差=9.7,范围41 - 84岁);76.3%(119例)为男性。住院死亡率为1.2%(2例患者)。房颤发生率为32.1%(50例),其中40%的房颤发作发生在术后第二天(范围1 - 6天)。单因素分析确定以下变量为房颤的危险因素:女性、年龄较大、种族、BMI>30、高血压、血脂异常、CABG术前使用硝酸盐、钙通道阻滞剂和呋塞米治疗、左心房直径、肾衰竭及CABG术后呼吸并发症(p<0.05)。多因素分析确定三个变量为独立预测因素:BMI>30(比值比2.4;95%可信区间1.2 - 4.8);西班牙裔犹太人(比值比11.2;可信区间1.0 - 114);左心房扩大(比值比4.6;可信区间1.5 - 14.1)。
与先前研究一致,左心房扩大是CABG术后房颤的预测因素。此外,种族(西班牙裔犹太人)和BMI>30也被发现是CABG术后房颤的重要预测因素。与其他研究相比,我们发现在内盖夫地区接受CABG的人群与全球研究相比,在结局和死亡率方面没有显著差异。