Ríos A, Ramírez P, Rodríguez M M, Martínez L, Rodríguez J M, Galindo P J, Parrilla P
Coordinación Regional de Trasplantes de la Comunidad Autónoma de Murcia, Consejería de Sanidad, Murcia, Spain. mailto:
Liver Transpl. 2007 Jul;13(7):1049-56. doi: 10.1002/lt.21226.
In Spain, despite its high rate of cadaveric donation, death while on the liver transplant waiting list is high. For this reason, living liver donation is being encouraged despite of the risk of morbidity for the donor. The objective of this study was to analyze attitudes toward living liver donation among hospital personnel in a hospital with a recently authorized living donor liver transplantation program. A random sample was taken and was stratified by type of service and job category (n = 1,262). Attitude was evaluated by means of a validated psychosocial questionnaire. The questionnaire was completed anonymously and was self-administered. Statistical analysis included the Student t test, the chi(2) test, and logistical regression analysis. The questionnaire completion rate was 93% (n = 1,168). Only 15% (n = 170) of respondents were in favor of living liver donation if it were unrelated. An additional 65% (n = 766) were in favor if this donation, but only for relatives. Of the rest, 9% (n = 107) did not agree with living liver donation, and the remaining 11% (n = 125) were undecided. The variables related to this attitude were age (P = 0.044); job category (P = 0.002); type of service (according to whether it is related to organ donation and transplantation) (P = 0.044); participation in prosocial activities (P = 0.026); attitude toward cadaveric organ donation (P <0.001); attitude of a respondent's partner toward organ donation (P = 0.010); a respondent's belief that in the future, he or she may need a transplant (P < 0.001); and a willingness to receive a donated living liver organ if one were needed (P < 0.001). There is also a close relationship between attitude toward living kidney donation and living liver donation (P < 0.001). In the multivariate analysis, the only common independent variable from the bivariate analysis was a willingness to receive a living donor liver transplant if one were needed (odds ratio = 9.3). Attitude toward living liver donation among hospital personnel in a hospital with a solid organ transplant program is favorable and is affected by factors related to cadaveric donation, altruistic activity, and feelings of reciprocity. Physicians and the youngest hospital workers are those who are most in favor, which leads us to think that there is a promising future for living liver transplantation, which is essential given the cadaveric organ deficit and the high mortality rate while on the waiting list.
在西班牙，尽管其尸体捐赠率很高，但肝移植等待名单上的患者死亡率也很高。因此，尽管存在供体发病风险，活体肝捐赠仍受到鼓励。本研究的目的是分析一家最近获批开展活体供体肝移植项目的医院中，医院工作人员对活体肝捐赠的态度。我们抽取了一个随机样本，并按服务类型和工作类别进行分层（n = 1262）。通过一份经过验证的社会心理问卷来评估态度。问卷采用匿名方式，由被调查者自行填写。统计分析包括学生t检验、卡方检验和逻辑回归分析。问卷完成率为93%（n = 1168）。只有15%（n = 170）的受访者支持非亲属间的活体肝捐赠。另外65%（n = 766）的受访者支持亲属间的活体肝捐赠。其余的受访者中，9%（n = 107）不同意活体肝捐赠，11%（n = 125）未作决定。与这种态度相关的变量包括年龄（P = 0.044）；工作类别（P = 0.002）；服务类型（根据是否与器官捐赠和移植相关）（P = 0.044）；参与亲社会活动（P = 0.026）；对尸体器官捐赠的态度（P <0.001）；受访者伴侣对器官捐赠的态度（P = 0.010）；受访者认为自己未来可能需要移植的信念（P <0.001）；以及如果需要是否愿意接受活体捐赠的肝脏器官（P <0.001）。对活体肾捐赠的态度与活体肝捐赠之间也存在密切关系（P <0.001）。在多变量分析中，双变量分析中唯一共同的独立变量是如果需要是否愿意接受活体供体肝移植（优势比 = 9.3）。在一家拥有实体器官移植项目的医院中，医院工作人员对活体肝捐赠的态度是积极的，并且受到与尸体捐赠、利他活动和互惠感相关的因素影响。医生和最年轻的医院工作人员是最支持的群体，这使我们认为活体肝移植有着光明的未来，鉴于尸体器官短缺以及等待名单上的高死亡率，这一点至关重要。
