Poupon R E, Heintzmann F, Valette I, Gervaise G, Edouard A, Monplaisir N, Dugoujon J M
INSERM, Unité 21, Villejuif, France.
Alcohol Alcohol. 1991;26(4):417-24. doi: 10.1093/oxfordjournals.alcalc.a045133.
The fact that only a small percentage of excessive drinkers develop cirrhosis may be due to a genetic susceptibility to the disease. In order to identify possible genetic risk factors for cirrhosis, we studied mixed-race (Negroid-Caucasian) inhabitants of the French West Indies and compared: (1) the frequency of 51 HLA-A, -B, -C and -DR antigens in 41 subjects with alcoholic cirrhosis and in two control groups consisting of 41 excessive drinkers free of liver disease and 51 healthy non-drinkers; and (2) the frequency of Gm and Km haplotypes in the same groups. Analysis of the Gm system also determined the patients' ethnic origins. The frequency of the HLA-A2 antigen was significantly higher in the cirrhotic patients than in the control group of excessive drinkers (chi 2 = 4.47; P less than 0.05), while that of the HLA-B15 antigen was significantly lower (chi 2 = 5.14; P less than 0.05). The frequency of the Cw4 antigen was significantly higher in the cirrhotics than in the non-drinkers (chi 2 = 5.59; P less than 0.05). However, these differences did not persist when the number of comparisons was taken into account. The frequency of Gm and Km haplotypes was not significantly different in the three groups. In conclusion, complementary studies are required to determine the value of the Gm-Km system as a marker of susceptibility to alcoholic cirrhosis. Our results do not identify an association between HLA antigens and cirrhosis specific to a negroid ethnic group and support the notion that such an association is weak.
只有一小部分酗酒者会发展为肝硬化，这一事实可能归因于对该疾病的遗传易感性。为了确定肝硬化可能的遗传风险因素，我们研究了法属西印度群岛的混血（黑人 - 高加索人）居民，并进行了以下比较：（1）在41例酒精性肝硬化患者以及由41名无肝脏疾病的酗酒者和51名健康非饮酒者组成的两个对照组中，检测51种HLA - A、-B、-C和 - DR抗原的频率；（2）在同一组中检测Gm和Km单倍型的频率。对Gm系统的分析还确定了患者的种族起源。肝硬化患者中HLA - A2抗原的频率显著高于酗酒者对照组（χ2 = 4.47；P < 0.05），而HLA - B15抗原的频率则显著较低（χ2 = 5.14；P < 0.05）。肝硬化患者中Cw4抗原的频率显著高于非饮酒者（χ2 = 5.59；P < 0.05）。然而，考虑到比较次数后，这些差异并未持续存在。三组中Gm和Km单倍型的频率没有显著差异。总之，需要进行补充研究来确定Gm - Km系统作为酒精性肝硬化易感性标志物的价值。我们的结果并未发现HLA抗原与特定黑人种族的肝硬化之间存在关联，并支持这种关联较弱的观点。
