Bell H, Nordhagen R
Scand J Gastroenterol. 1980;15(4):453-6. doi: 10.3109/00365528009181499.
HLA antigen determination showed that the frequency of HLA-B40 was significantly increased (49%) in 43 patients with alcoholic cirrhosis, compared with the frequency found in 234 healthy blood donors (18%). The HLA-B40 frequency was not increased in three other patient groups: 36 patients with alcoholic liver disease without cirrhosis (14%), 21 patients with miscellaneous liver disease (24%), and 26 alcoholics without liver disease (24%). We could not confirm the previously reported association between advanced alcoholic liver damage and HLA-B8, which has been taken as support for the relation to autoimmune mechanisms. The association with HLA-B40, however, favours the idea that genetically determined individual susceptibility to alcoholic liver cirrhosis may exist.
人类白细胞抗原（HLA）抗原检测显示，43例酒精性肝硬化患者中HLA - B40的频率显著升高（49%），相比之下，234名健康献血者中的频率为18%。在其他三组患者中，HLA - B40频率并未升高：36例无肝硬化的酒精性肝病患者（14%）、21例其他肝病患者（24%）以及26例无肝病的酗酒者（24%）。我们无法证实先前报道的晚期酒精性肝损伤与HLA - B8之间的关联，该关联曾被视为与自身免疫机制相关的证据。然而，与HLA - B40的关联支持了可能存在由基因决定的个体对酒精性肝硬化易感性的观点。
