Sutin Lori, Andersson Sören, Bergquist Lars, Castro Victor M, Danielsson Eva, James Stephen, Henriksson Martin, Johansson Lars, Kaiser Christina, Flyrén Katarina, Williams Meredith
Biovitrum AB, SE-112 76, Stockholm, Sweden.
Bioorg Med Chem Lett. 2007 Sep 1;17(17):4837-40. doi: 10.1016/j.bmcl.2007.06.054. Epub 2007 Jun 20.
2,5,5-Trisubstituted oxazolones were identified as potent inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1). The synthesis, structure-activity relationship and metabolic stability of these compounds are presented.
2,5,5-三取代恶唑酮被鉴定为11β-羟基类固醇脱氢酶1型（11β-HSD1）的强效抑制剂。本文介绍了这些化合物的合成、构效关系和代谢稳定性。
