β-氨基-α-三氟甲基醇的合成及其在有机合成中的应用。
Synthesis of β-amino-α-trifluoromethyl alcohols and their applications in organic synthesis.
作者信息
Mlostoń Grzegorz, Obijalska Emilia, Heimgartner Heinz
机构信息
Department of Organic and Applied Chemistry, University of Łódź, Tamka 12, PL-91-403, Łódź, Poland.
Institute of Organic Chemistry, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland.
出版信息
J Fluor Chem. 2010 Aug;131(8):829-843. doi: 10.1016/j.jfluchem.2010.05.014. Epub 2010 Jun 4.
A comprehensive overview on methods applied for syntheses of β-amino-α-trifluoromethyl alcohols, including stereocontrolled variants, is presented. In addition, reported cases of the exploration of β-amino-α-trifluoromethyl alcohols for the preparation of trifluoromethylated peptidomimetics and other biologically active, fluorinated compounds are discussed. Attractive opportunities for their applications as organocatalysts are also presented.
本文对用于合成β-氨基-α-三氟甲基醇的方法进行了全面概述，包括立体控制变体。此外，还讨论了已报道的探索β-氨基-α-三氟甲基醇用于制备三氟甲基化肽模拟物和其他生物活性含氟化合物的案例。还介绍了它们作为有机催化剂应用的诱人机会。
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