Rossi G F, Colicchio G, Pola P, Roselli R
Istituto di Neurochirurgia, Università Cattolica del Sacro Cuore, Rome, Italy.
Epilepsy Res Suppl. 1991;2:23-30.
Thirteen patients suffering from severe partial epilepsy and potential candidates for surgical treatment were investigated with stereotactically implanted intracerebral electrodes during nocturnal physiological sleep. The recorded electrocerebral activity was automatically analyzed to gain information on interictal epileptic events during wakefulness and the phases of sleep. The interictal epileptic activity shows: (1) great variability in the different subjects, and intra-individually, variability according to the explored cerebral regions; (2) is not influenced by the location of the recorded epileptic events; and (3) is affected by the local level of epileptogenicity. The latter was determined by the assessment of the capacity to give origin to ictal discharges and the disappearance of seizures following surgical removal. The interictal rate of spiking from the most epileptogenic cerebral zone is characterized by a relative stability during the night and by a relatively high degree during REM sleep.
对13名患有严重部分性癫痫且有可能接受手术治疗的患者，在夜间生理性睡眠期间使用立体定向植入的脑内电极进行了研究。对记录的脑电活动进行自动分析，以获取有关清醒期和睡眠各阶段发作间期癫痫事件的信息。发作间期癫痫活动表现为：（1）不同受试者之间以及个体内部根据所探索的脑区存在很大差异；（2）不受记录到的癫痫事件位置的影响；（3）受局部致痫性水平的影响。后者通过评估引发发作性放电的能力以及手术切除后癫痫发作的消失情况来确定。来自致痫性最强脑区的发作间期棘波频率在夜间具有相对稳定性，在快速眼动睡眠期间频率相对较高。
