玻璃体内注射曲安奈德对渗出性黄斑变性中黄斑中心凹水肿的影响。

The effect of intravitreal triamcinolone on foveal edema in exudative macular degeneration.

作者信息

Gillies Mark C, Larsson Jorgen

机构信息

Department of Clinical Ophthalmology, Save Sight Institute, University of Sydney, Sydney, Australia.

出版信息

Am J Ophthalmol. 2007 Jul;144(1):134-6. doi: 10.1016/j.ajo.2007.03.019.

DOI:10.1016/j.ajo.2007.03.019

PMID:17601437

Abstract

PURPOSE

To evaluate the effect of a single intravitreal injection of triamcinolone (IVTA) on central macular thickness and visual acuity in eyes with minimally classic exudative age-related macular degeneration (AMD).

DESIGN

Retrospective, nonrandomized clinical interventional study.

METHODS

Optical coherence tomography (OCT) and best-corrected logarithm of the minimum angle of resolution visual acuity were performed at baseline and one month after treatment.

RESULTS

We identified 11 eyes with foveal edema and minimally classic subfoveal neovascularization treated with an IVTA. Foveal edema decreased significantly from 401 +/- 98 microm at baseline to 295 +/- 141 microm (mean +/- standard deviation; P = .004) at one month. There was, however, no significant change in visual acuity at one or three months after the intervention.

CONCLUSIONS

This biological effect of IVTA does not support its clinical use, yet it does warrant further research to determine whether locally delivered corticosteroids may be synergistic with other treatments. Reduction in foveal edema is not necessarily associated with improved visual function in exudative AMD.

摘要