Gillies Mark C, Larsson Jorgen
Department of Clinical Ophthalmology, Save Sight Institute, University of Sydney, Sydney, Australia.
Am J Ophthalmol. 2007 Jul;144(1):134-6. doi: 10.1016/j.ajo.2007.03.019.
To evaluate the effect of a single intravitreal injection of triamcinolone (IVTA) on central macular thickness and visual acuity in eyes with minimally classic exudative age-related macular degeneration (AMD).
Retrospective, nonrandomized clinical interventional study.
Optical coherence tomography (OCT) and best-corrected logarithm of the minimum angle of resolution visual acuity were performed at baseline and one month after treatment.
We identified 11 eyes with foveal edema and minimally classic subfoveal neovascularization treated with an IVTA. Foveal edema decreased significantly from 401 +/- 98 microm at baseline to 295 +/- 141 microm (mean +/- standard deviation; P = .004) at one month. There was, however, no significant change in visual acuity at one or three months after the intervention.
This biological effect of IVTA does not support its clinical use, yet it does warrant further research to determine whether locally delivered corticosteroids may be synergistic with other treatments. Reduction in foveal edema is not necessarily associated with improved visual function in exudative AMD.
评估单次玻璃体内注射曲安奈德（IVTA）对轻度典型渗出性年龄相关性黄斑变性（AMD）患者黄斑中心厚度和视力的影响。
回顾性、非随机临床干预研究。
在基线和治疗后1个月进行光学相干断层扫描（OCT）和最佳矫正最小分辨角对数视力检查。
我们纳入了11只患有黄斑水肿和轻度典型黄斑下新生血管的眼睛，接受了IVTA治疗。黄斑水肿从基线时的401±98微米显著降至1个月时的295±141微米（平均值±标准差；P = 0.004）。然而，干预后1个月或3个月时视力无显著变化。
IVTA的这种生物学效应不支持其临床应用，但确实值得进一步研究以确定局部递送的皮质类固醇是否可能与其他治疗协同作用。在渗出性AMD中，黄斑水肿的减轻不一定与视觉功能改善相关。
