对源自对硝基苯甲醛的具有生物活性的新型席夫碱的合成、光谱及细胞毒性研究。
Synthesis, spectroscopic and cytotoxic studies of biologically active new schiff bases derived from p-nitrobenzaldehyde.
作者信息
Iqbal Amjid, Siddiqui Hamid Latif, Ashraf Chaudhary Muhammad, Bukhari Mujahid Hussain, Akram Chaudhary Muhammad
机构信息
Institute of Chemistry, University of the Punjab, Lahore, Pakistan.
出版信息
Chem Pharm Bull (Tokyo). 2007 Jul;55(7):1070-2. doi: 10.1248/cpb.55.1070.
Thirteen new Schiff bases derived from p-nitrobenzaldehyde were synthesized by condensation with the appropriate amines. An unusual reduction of the p-nitrobenzaldehyde to the corresponding alcohol was also observed in one of the reactions. The structures of the compounds were identified using spectroscopic techniques. Cytotoxicity for the titled compounds was studied against Brine Shrimp, used as the test animal.
通过与适当的胺缩合反应，合成了13种由对硝基苯甲醛衍生而来的新型席夫碱。在其中一个反应中，还观察到了对硝基苯甲醛异常还原为相应醇的现象。使用光谱技术对这些化合物的结构进行了鉴定。以卤虫作为实验动物，研究了标题化合物的细胞毒性。
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