Department of Chemistry, Bahauddin Zakariya University , Multan , Pakistan.
J Enzyme Inhib Med Chem. 2013 Dec;28(6):1291-9. doi: 10.3109/14756366.2012.735666. Epub 2012 Nov 2.
The condensation reaction of 3,5-diamino-1,2,4-triazole with methoxy-, chloro-, bromo-, iodo- and nitro-substituted 2-hydroxybenzaldehydes formed triazole Schiff bases (L(1))-(L(6)). The synthesized ligands have been characterized through physical, spectral and analytical data. Furthermore, the reaction of synthesized Schiff bases with the oxovanadium(IV) sulphate in (1:2) (metal:ligand) molar ratio afforded the oxovanadium(IV) complexes (1)-(6). All the complexes were non-electrolytic and showed a square-pyramidal geometry. The synthesized compounds have been screened for in-vitro antibacterial, antifungal and brine shrimp bioassay. The bioactivity data showed the complexes to be more active than the original Schiff bases.
3,5-二氨基-1,2,4-三唑与甲氧基、氯代、溴代、碘代和硝基取代的 2-羟基苯甲醛的缩合反应形成三唑席夫碱（L(1))-(L(6))。通过物理、光谱和分析数据对合成配体进行了表征。此外，合成的席夫碱与硫酸氧钒（IV）以（1:2）（金属：配体）摩尔比反应，得到氧钒（IV）配合物（1）-(6)。所有配合物均为非电解质，呈四方锥几何形状。合成的化合物进行了体外抗菌、抗真菌和卤虫生物测定筛选。生物活性数据表明，配合物比原始席夫碱更具活性。
