Inorganic & Bioinorganic Research Lab, Department of Chemistry, Govt. Post Graduate College, Ranikhet 263645 (Uttarakhand), India.
Spectrochim Acta A Mol Biomol Spectrosc. 2012 Aug;94:143-51. doi: 10.1016/j.saa.2012.03.077. Epub 2012 Apr 4.
Schiff bases derived from 2-nitrobenzaldehyde with amino acids (glycine, methionine) and their Co(II), Ni(II) and Cu(II) complexes have been synthesized and characterized by various physico-chemical techniques. From spectral studies, it has been concluded that the ligands acts as bidentate molecule, coordinates metal through azomethine nitrogen and carboxylate oxygen. Mass spectrum explains the successive degradation of the molecular species in solution and justifies ML(2) complexes. X-ray powder diffraction helps to determine the cell parameters of the complexes. Molecular structure of the complexes has been optimized by MM2 calculations and suggests a square planar geometry. The ligands and their metal complexes have been tested in vitro against Streptococcus, Staph, Staphylococcus aureus and Escherchia coli bacteria in order to assess their antibacterial potential. The results indicate that the biological activity increases on complexation.
席夫碱是由 2-硝基苯甲醛与氨基酸（甘氨酸、甲硫氨酸）及其 Co(II)、Ni(II)和 Cu(II)配合物合成的，并用各种物理化学技术进行了表征。从光谱研究中可以得出结论，配体作为双齿分子，通过亚甲胺氮和羧酸盐氧与金属配位。质谱解释了溶液中分子物种的连续降解，并证明了 ML(2)配合物的存在。X 射线粉末衍射有助于确定配合物的晶胞参数。通过 MM2 计算对配合物的分子结构进行了优化，表明其具有平面四方几何构型。为了评估其抗菌潜力，对配体及其金属配合物进行了体外抗链球菌、葡萄球菌、金黄色葡萄球菌和大肠杆菌的测试。结果表明，配合物的生物活性增加。
