Babu P R Sathesh, Subrahmanyam C V S, Thimmasetty J, Manavalan R, Valliappan K
Bapuji Pharmacy College, Davangere, Karnataka, India.
Pak J Pharm Sci. 2007 Oct;20(4):311-6.
The solubility behaviour of meloxicam in individual solvents ranging from non-polar to highly polar was studied. For understanding the solute-solvent interactions, partial solubility parameters concept was utilized. The extended Hansen's method was used for analyzing the solubility data and for obtaining partial solubility parameters of meloxicam. The analysis was not successful though correlations were 81%. The Flory-Huggins size correction term 'B' was found to improve the prediction of solubility. The correlations were high (92%) and total solubility parameter was 11.6 H. The four-parameter approach involving proton-donor and proton-acceptor parameters was also used in fitting the solubility data. The correlations were appreciable (87%) and total solubility parameter was 11.2 H. The term 'B' combined with four-parameter approach was also used in order to improve the data, and was found to be improved the correlations (R2=0.94). This new approach may thus be used in fitting the experimental solubility data and to predict solubility behaviour of meloxicam in untested solvents. The total solubility parameter of meloxicam was assigned at 11.2 H.
研究了美洛昔康在从非极性到高极性的各种单一溶剂中的溶解行为。为了理解溶质 - 溶剂相互作用，采用了部分溶解度参数概念。扩展的汉森方法用于分析溶解度数据并获得美洛昔康的部分溶解度参数。尽管相关性为81%，但分析并不成功。发现弗洛里 - 哈金斯尺寸校正项“B”可改善溶解度预测。相关性很高（92%），总溶解度参数为11.6 H。涉及质子供体和质子受体参数的四参数方法也用于拟合溶解度数据。相关性相当可观（87%），总溶解度参数为11.2 H。“B”项与四参数方法相结合也用于改进数据，发现相关性得到了提高（R2 = 0.94）。因此，这种新方法可用于拟合实验溶解度数据并预测美洛昔康在未测试溶剂中的溶解行为。美洛昔康的总溶解度参数设定为11.2 H。
