Bustamante P, Escalera B, Martin A, Sellés E
Departamento de Farmacia Galénica, Facultad de Farmacia, Universidad de Alcalá de Henares, Madrid, Spain.
J Pharm Sci. 1989 Jul;78(7):567-73. doi: 10.1002/jps.2600780712.
Sulfamethoxypyridazine, a representative model of a drug molecule, is used to test the extended Hansen method for estimating partial solubility parameters of solid compounds. Solubilities are determined in polar and nonpolar solvents. The method provides reasonable partial parameters for the sulfonamide, and it may be useful in obtaining partial parameters for other drug molecules. A four-parameter extended Hansen approach involving proton donor and acceptor parameters is used in fitting the data to a theoretical model. A term, Wh, is introduced as an empirical measure of solute-solvent interactions due to hydrogen bonding. The use of the empirical term Wh allows the researcher to fit experimental solubilities and thus design regression models and equations which provide a reasonable prediction of solubilities of a polar drug in a number of very different solvents. A Flory-Huggins size correction term improves the prediction of sulfamethoxypyridazine solubilities in these irregular solutions.
磺胺甲氧嗪是药物分子的一个典型模型，用于测试扩展的汉森方法以估算固体化合物的部分溶解度参数。在极性和非极性溶剂中测定溶解度。该方法为磺胺类药物提供了合理的部分参数，可能有助于获取其他药物分子的部分参数。一种涉及质子供体和受体参数的四参数扩展汉森方法用于将数据拟合到理论模型。引入术语Wh作为氢键引起的溶质 - 溶剂相互作用的经验度量。使用经验术语Wh使研究人员能够拟合实验溶解度，从而设计回归模型和方程，这些模型和方程能够合理预测极性药物在多种非常不同溶剂中的溶解度。弗洛里 - 哈金斯尺寸校正项改善了磺胺甲氧嗪在这些非理想溶液中溶解度的预测。
