垂直排列的碳纳米纤维阵列记录海马切片的电生理信号。

Vertically aligned carbon nanofiber arrays record electrophysiological signals from hippocampal slices.

作者信息

Yu Zhe, McKnight Timothy E, Ericson M Nance, Melechko Anatoli V, Simpson Michael L, Morrison Barclay

机构信息

Department of Biomedical Engineering, Columbia University, 1210 Amsterdam Avenue, 351 Engineering Terrace, New York, New York 10027, USA.

出版信息

Nano Lett. 2007 Aug;7(8):2188-95. doi: 10.1021/nl070291a. Epub 2007 Jun 30.

DOI:10.1021/nl070291a

PMID:17604402

Abstract

Vertically aligned carbon nanofiber (VACNF) electrode arrays were tested for their potential application in recording neuro-electrophysiological activity. We report, for the first time, stimulation and extracellular recording of spontaneous and evoked neuroelectrical activity in organotypic hippocampal slice cultures with ultramicroelectrode VACNF arrays. Because the electrodes are carbon-based, these arrays have potential advantages over metal electrodes and could enable a variety of future applications as precise, informative, and biocompatible neural interfaces.

摘要

对垂直排列的碳纳米纤维（VACNF）电极阵列在记录神经电生理活动方面的潜在应用进行了测试。我们首次报告了使用超微电极VACNF阵列对器官型海马切片培养物中的自发和诱发神经电活动进行刺激和细胞外记录。由于电极是基于碳的，这些阵列相对于金属电极具有潜在优势，并有望在未来作为精确、信息丰富且生物相容的神经接口实现多种应用。