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对于一位问诊和临床检查均严格正常的患者,实施产科硬膜外麻醉时是否有必要进行生物学评估?

[Is a biological assessment necessary to realize an obstetrical epidural anaesthesia in a patient whose interrogation and clinical examination are strictly normal?].

作者信息

Nathan N, Sol I, Vincelot A, Collet D, Granchamp P, David E

机构信息

Département d'anesthésie-réanimation, CHU Dupuytren, Limoges cedex, France.

出版信息

Ann Fr Anesth Reanim. 2007 Jul-Aug;26(7-8):705-10. doi: 10.1016/j.annfar.2007.05.007. Epub 2007 Jun 28.

DOI:10.1016/j.annfar.2007.05.007
PMID:17604589
Abstract

In France, coagulation blood tests are usually ordered before performing an epidural anaesthesia. This French habit obeys to the fear of triggering an epidural haematoma induced by neuraxial anaesthesia. This analysis of literature shows that these practices do not protect anaesthesiologists against this clinical risk or its medico-legal consequences. As shown by epidemiological studies, epidural haematoma in pregnancy is associated to the occurrence of HELLP syndrome. On the opposite, gestational thrombocytopenia is not associated to any bleeding risk. According to the recommendations of the French Society of Anaesthesia (Sfar), only a clinical examination and an interrogatory must be done to diagnose coagulation defects before general or loco regional anaesthesia. Normal pregnancy is not an exception to this rule except for the platelet number which must be evaluated during the 3rd trimester of pregnancy. This platelet numeration might detect a rare idiopathic thrombopenic purpura. This recommendation is valid only for normal pregnancy. The clinician must ensure that pregnancy is still normal by seeking for symptoms of pregnancy-induced pathology such as preeclampsia or HELLP syndrome before setting an epidural anaesthesia. The possibly late occurrence of these complications during the per- or post-partum explain why a coagulation test performed even a few days before anaesthesia may not allow to detect any coagulation defect favouring the risk of epidural haematoma.

摘要

在法国,通常会在进行硬膜外麻醉前安排凝血功能血液检查。这种法国人的习惯是出于对引发神经轴索麻醉所致硬膜外血肿的恐惧。对文献的分析表明,这些做法并不能使麻醉医生免受这种临床风险或其法律后果的影响。正如流行病学研究所示,妊娠期硬膜外血肿与HELLP综合征的发生有关。相反,妊娠期血小板减少症与任何出血风险均无关。根据法国麻醉学会(Sfar)的建议,在进行全身或局部区域麻醉前,仅需进行临床检查和问诊以诊断凝血功能缺陷。正常妊娠并非此规则的例外情况,不过在妊娠晚期必须评估血小板数量。这种血小板计数可能会检测出罕见的特发性血小板减少性紫癜。该建议仅适用于正常妊娠。在进行硬膜外麻醉前,临床医生必须通过寻找妊娠相关病理症状,如先兆子痫或HELLP综合征,来确保妊娠仍属正常。这些并发症在围产期或产后可能较晚出现,这就解释了为何即使在麻醉前几天进行凝血功能检查,也可能无法检测出任何增加硬膜外血肿风险的凝血功能缺陷。

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引用本文的文献

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Minimally invasive spinal anesthesia for cesarean section in maternal anticoagulation therapy: a randomized controlled trial.母体抗凝治疗中剖宫产术的微创脊柱麻醉:一项随机对照试验。
BMC Anesthesiol. 2019 Jan 12;19(1):11. doi: 10.1186/s12871-018-0679-1.
2
Thrombocytopenia in Pregnancy.妊娠期血小板减少症
Maedica (Bucur). 2016 Mar;11(1):55-60.