Yildiz Serpil Kuyucu, Koybasi Serap, Turkoglu Sule Aydin, Yildiz Nebil, Korkmaz Bektas, Akyurek Fatma
Department of Neurology, Abant Izzet Baysal University, Izzet Baysal Medical Faculty, Bolu, Turkey.
Clin Neurophysiol. 2007 Sep;118(9):1991-8. doi: 10.1016/j.clinph.2007.05.069. Epub 2007 Jun 28.
To investigate the sympathetic nervous system activity in Meniere's disease (MD) by recording sympathetic skin responses (SSRs) from the postauricular region (PA).
Twenty-one patients with definite unilateral MD diagnosis and 12 healthy volunteers were studied by evoking right and left PA-SSRs with electrical stimulation of the left median nerve at the wrist in attack and interval periods of MD. Mean latencies and maximum amplitudes were used in statistical analyses.
In unilateral definite MD patients, the mean latencies were longer and the maximum amplitudes were smaller on the involved ear side than those on the normal ear side (p<0.01 for both amplitude and latency) and than those from the controls (p<0.01 and p<0.05). In three patients, there was no detectable PA-SSR on the involved ear side while there were SSRs on the healthy side. In four patients, the responses were absent bilaterally during the attack period.
There is a marked asymmetric sympathetic hypofunction in the area of the PA region of the involved ear in MD patients.
The PA region is a new site for recording sympathetic skin responses. PA-SSR is a useful tool to investigate sympathetic nervous system function in MD patients.
