Skarpaas T, Ljøstad U, Søbye M, Mygland A
Microbiology Unit, Division of Laboratory Medicine, Sørlandet Hospital HF, Service Box 416, 4604, Kristiansand, Norway.
Eur J Clin Microbiol Infect Dis. 2007 Sep;26(9):675-7. doi: 10.1007/s10096-007-0336-y.
The purpose of this study was to evaluate the diagnostic sensitivity and specificity of a commercial C6 enzyme immuno assay, QuickC6, in acute Lyme neuroborreliosis (LNB) in endemic areas. Paired sera and cerebral spinal fluids (CSFs) from 60 patients with definite LNB, eight patients with possible LNB, 18 patients with conditions mimicking LNB and 42 persons with noninfectious neurological disease were examined. The case definition of LNB was based on strict criteria during a prospective 4-month follow-up. The sensitivity of QuickC6 was 98% both in sera and CSFs, and the diagnostic specificity was 61% in sera and 88% in CSFs. QuickC6 is a sensitive, simple and cost-effective screening test in serum and CSF in diagnosis of acute LNB. Specificity needs further evaluation.
本研究的目的是评估一种商业化的C6酶免疫测定法QuickC6在流行地区急性莱姆病神经伯氏疏螺旋体病（LNB）中的诊断敏感性和特异性。对60例确诊LNB患者、8例可能患有LNB的患者、18例疑似LNB的患者以及42例非感染性神经疾病患者的配对血清和脑脊液（CSF）进行了检测。LNB的病例定义基于前瞻性4个月随访期间的严格标准。QuickC6在血清和脑脊液中的敏感性均为98%，血清中的诊断特异性为61%，脑脊液中的诊断特异性为88%。QuickC6是一种用于血清和脑脊液中急性LNB诊断的敏感、简单且经济高效的筛查试验。特异性需要进一步评估。
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