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肾移植患者发生寄生拟青霉皮下感染,经手术成功治疗。

Phaeoacremonium parasiticum subcutaneous infection in a kidney-transplanted patient successfully treated by surgery.

作者信息

Farina C, Gotti E, Mouniée D, Boiron P, Goglio A

机构信息

Microbiology Institute, Azienda Ospedaliera Ospedali Riuniti di Bergamo, Bergamo, Italy.

出版信息

Transpl Infect Dis. 2007 Sep;9(3):253-5. doi: 10.1111/j.1399-3062.2007.00206.x. Epub 2007 Jul 1.

Abstract

Human infection caused by Phaeoacremonium parasiticum is increasingly being reported. However, only a few case reports show its role as a soil-related contaminant of kidney recipients. We report here a case of a subcutaneous infection by P. parasiticum in a transplanted man. After 4 years, he reported a nonpainful nodule on his forefinger. It was surgically excised. Histological examination revealed dense fibrous connective tissue showing an extensive granulomatous reaction, including the presence of a wooden sliver, and hyaline, branched, and septate hyphae. Six months later, the patient relapsed and underwent large excision. Culture was positive for P. parasiticum. No antifungal drug was administered. Surgical excision was successful.

摘要

由寄生拟青霉引起的人类感染报告日益增多。然而,仅有少数病例报告显示其作为肾移植受者与土壤相关污染物的作用。我们在此报告一例移植男性发生的寄生拟青霉皮下感染病例。4年后,他报告食指出现一个无痛性结节。该结节经手术切除。组织学检查显示致密的纤维结缔组织呈现广泛的肉芽肿反应,包括存在一根木刺以及透明、分支和有隔膜的菌丝。6个月后,患者复发并接受了大范围切除。培养结果显示寄生拟青霉阳性。未给予抗真菌药物。手术切除成功。

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