在肾移植受者中：强调早期识别和手术清创的重要性。
in Kidney Transplant Recipients: Highlighting the Importance of Early Recognition and Surgical Debridement.
作者信息
Singla Animesh A, Garg Priya, Chui Juanita N, Pham David, Webb-Harvey Zachary J, Halliday Catriona L, De Silva Ramesh, Hameed Ahmer, Nulend Rowan Klein, Lee Taina, Wong Germaine, Pleass Henry
机构信息
Transplant Surgery Department, Westmead Hospital, NSW, Australia.
Faculty of Medicine, Sydney University, NSW, Australia.
出版信息
Transplant Direct. 2022 Dec 12;9(1):e1430. doi: 10.1097/TXD.0000000000001430. eCollection 2023 Jan.
UNLABELLED
Fungal infections are a recognized complication of immunosuppression in solid organ transplant recipients. Phaeohyphomycoses are fungal infections caused by a diverse group of dematiaceous fungi.
METHODS
We share the learning points from 2 Australian cases of phaeohyphomycosis secondary to species (spp). A literature review was performed using Medline, Embase, and Google Scholar to identify this condition among kidney transplant recipients.
RESULTS
With the 2 cases reported in this article, a total of 17 cases were identified in the literature. spp is ubiquitous in humid and temperate flora, including Australia. Minor trauma is likely the source of inoculation in most cases and diagnosis is often delayed. Presently, no guidelines for management exist given the rarity of this condition. Most known cases have been treated with surgical debulking combined with long-course antifungal therapy.
CONCLUSION
This paper describes 2 Australian cases of phaeohyphomycosis in kidney transplant recipients. A high index of suspicion, especially in the immunosuppressed, is essential for timely diagnosis in kidney transplant recipients. There are several diagnostic and therapeutic challenges that remain with this condition.
未标注
真菌感染是实体器官移植受者免疫抑制的一种公认并发症。暗色丝孢霉病是由多种暗色真菌引起的真菌感染。
方法
我们分享了2例澳大利亚继发于某菌种的暗色丝孢霉病病例的经验教训。使用Medline、Embase和谷歌学术进行文献综述，以确定肾移植受者中的这种疾病。
结果
结合本文报道的2例病例，文献中总共确定了17例。该菌种在包括澳大利亚在内的潮湿和温带植物群中普遍存在。在大多数情况下，轻微创伤可能是接种源，诊断往往延迟。由于这种疾病罕见，目前尚无管理指南。大多数已知病例采用手术减瘤联合长期抗真菌治疗。
结论
本文描述了2例澳大利亚肾移植受者的暗色丝孢霉病病例。高度怀疑指数，尤其是对免疫抑制患者，对于肾移植受者的及时诊断至关重要。这种疾病仍然存在一些诊断和治疗挑战。
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