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心血管疾病预防指南中的血脂管理:实施策略与方法

Lipid management in cardiovascular disease prevention guidelines: strategies and tactics for implementation.

作者信息

Erhardt Leif R, Leiter Lawrence A, Hobbs F D Richard

机构信息

Department of Cardiology, Malmö University Hospital, Malmö, Sweden.

出版信息

Atherosclerosis. 2008 Feb;196(2):532-41. doi: 10.1016/j.atherosclerosis.2007.05.017. Epub 2007 Jul 2.

Abstract

Despite the widespread dissemination of clinical practice guidelines on the prevention and treatment of cardiovascular disease (CVD), CVD causes one third of deaths worldwide and almost half of all deaths in the developed world. It is therefore likely that, although some aspects of CVD management have improved, there is still a significant shortfall between what is known about CVD prevention and what is put into action. Twenty-one experts in the field of CVD from around the world attended a focus panel meeting in Marlow-on-Thames, UK (see acknowledgements for a list of meeting participants). These experts were invited to discuss practical strategies and tactics for overcoming barriers to the implementation of guidelines on CVD prevention, and lipid management in particular. This article reviews and updates the key topics presented during the course of the meeting, captures the essence of the group discussions, and summarizes the meeting outcomes. The participants concluded that initial efforts to implement CVD prevention guidelines more effectively are best directed at high-risk patients who have already been identified. Once current patients achieve their targets, more attention can be paid to finding untreated patients at risk. Recommendations from the expert panel included: Harmonize guidelines; focus on common areas of consensus rather than state-of-the-art science. Remove the boundary between primary and secondary prevention and focus on level of overall risk. Help policy makers understand the different components of CVD. Include professional societies from different specialties in guideline development and implementation, to increase ownership and decrease fragmentation of guideline committees.

摘要

尽管关于心血管疾病(CVD)预防和治疗的临床实践指南已广泛传播,但CVD在全球导致三分之一的死亡,在发达国家几乎占所有死亡人数的一半。因此,虽然CVD管理的某些方面有所改善,但在CVD预防的已知知识与实际行动之间可能仍存在重大差距。来自世界各地的21位CVD领域专家参加了在英国泰晤士河畔马洛举行的焦点小组会议(会议参与者名单见致谢部分)。邀请这些专家讨论克服CVD预防指南实施障碍的实际策略和战术,特别是脂质管理。本文回顾并更新了会议期间提出的关键主题,提炼了小组讨论的要点,并总结了会议成果。与会者得出结论,更有效地实施CVD预防指南的初步努力最好针对已确定的高危患者。一旦现有患者达到目标,就可以更多地关注寻找未接受治疗的高危患者。专家小组的建议包括:协调指南;关注共识的共同领域而非最新科学。消除一级预防和二级预防之间的界限,关注总体风险水平。帮助政策制定者了解CVD的不同组成部分。将来自不同专业的专业协会纳入指南的制定和实施,以增强归属感并减少指南委员会的分散性。

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