Vigne Paul, Frelin Christian
Inserm U615, Nice F-06108, France.
Mech Ageing Dev. 2007 May-Jun;128(5-6):401-6. doi: 10.1016/j.mad.2007.05.008. Epub 2007 May 25.
Relationships between nutrition and longevity are of growing interest. Here we analysed the influences of dietary restriction on the survival of Drosophila exposed to atmospheric oxygen or to chronic hypoxia. Dietary restriction was achieved by food dilution, by sucrose restriction or by yeast restriction. Sucrose and yeast influenced survival in a complex manner that was best visualised using a phenotypic landscape metaphor. Survival contour maps integrate poorly understood behavioural adaptations, metabolic regulations and nutrient signalling pathways in a comprehensive manner. Dietary yeast produced a bell shaped survival response which was dependent on sucrose. Hypoxic flies had a reduced longevity as compared to normoxic flies and their dependence on specific nutrients was modified. Yeast which was beneficial to normoxic flies was toxic for hypoxic flies. In addition hypoxic flies were more resistant to starvation. We conclude that the survival and the hypoxic tolerance of Drosophila have different nutritional requirements.
营养与长寿之间的关系越来越受到关注。在此，我们分析了饮食限制对暴露于大气氧或慢性低氧环境下的果蝇存活的影响。饮食限制通过食物稀释、蔗糖限制或酵母限制来实现。蔗糖和酵母以复杂的方式影响存活，使用表型景观隐喻能最好地呈现这种方式。存活等高线图以综合的方式整合了理解不足的行为适应、代谢调节和营养信号通路。饮食酵母产生了一种钟形的存活反应，该反应依赖于蔗糖。与常氧果蝇相比，低氧果蝇的寿命缩短，并且它们对特定营养素的依赖性发生了改变。对常氧果蝇有益的酵母对低氧果蝇有毒。此外，低氧果蝇对饥饿更具抵抗力。我们得出结论，果蝇的存活和低氧耐受性有不同的营养需求。
