Pletcher Scott D, Libert Sergiy, Skorupa Danielle
Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
Ageing Res Rev. 2005 Nov;4(4):451-80. doi: 10.1016/j.arr.2005.06.007. Epub 2005 Nov 2.
Reduced nutrient availability (dietary restriction) extends lifespan in species as diverse as yeast, nematode worms, Daphnia, Drosophila, and mammals. Recent demographic experiments have shown that moderate nutrient manipulation in adult Drosophila affects current mortality rate in a completely reversible manner, which suggests that dietary restriction in Drosophila increases lifespan through a reduction of the current risk of death rather than a slowing of aging-related damage. When examined in the light of the new demographic data, age-dependent changes in gene expression in normal and diet-restricted flies can provide unique insight into the biological processes affected by aging and may help identify molecular pathways that regulate it.
营养可利用性降低（饮食限制）可延长多种物种的寿命，如酵母、线虫、水蚤、果蝇和哺乳动物。最近的人口统计学实验表明，成年果蝇的适度营养调控会以完全可逆的方式影响当前死亡率，这表明果蝇的饮食限制通过降低当前的死亡风险而非减缓与衰老相关的损伤来延长寿命。根据新的人口统计学数据进行研究时，正常和饮食受限果蝇中基因表达的年龄依赖性变化可以为受衰老影响的生物学过程提供独特的见解，并可能有助于识别调控衰老的分子途径。
