Total body irradiation in the conditioning regimen for hematological malignancies.

The role of Total Body Irradiation (TBI) is well defined in the conditioning regimen for BMT, but in pediatric malignancies there are some particular points of discussion, due to the side effects of irradiation. As alternative methods have been described, as Busulfan based regimens, a critical balance between efficacy and toxicities has to be considered in this subset of patients.