Bushe Chris, Shaw Michael
Eli Lilly and Company Ltd, Basingstoke, UK.
J Psychopharmacol. 2007 Sep;21(7):768-73. doi: 10.1177/0269881107078281. Epub 2007 Jul 2.
Hyperprolactinaemia is a common finding in patients treated with antipsychotics. A complete cohort of 194 schizophrenia and bipolar disorder patients receiving antipsychotics in a single community mental health trust in Halifax UK underwent routine prolactin screening in the absence of any reLevant symptomatoLogy. Values above the upper limit of normal were measured in 38% of the cohort and were more common in females (52%) than males (26%). Significantly elevated levels (>1000 mIU/l) were measured in 21% of the cohort. Risperidone monotherapy treatment was associated with hyperprolactinaemia in 69% of patients ( n = 35) and in 100% of female patients (n = 16) and amisulpride monotherapy in 100% (n = 7). Prolactin screening is not currently undertaken routinely in the UK. These data give some indication of prevalence of varying degrees of hyperproLactinaemia that might be found when screening an asymptomatic cohort of schizophrenia and bipolar outpatients. Clinicians may be helped by the reporting of such categorical data from clinical trials in addition to mean cohort values of prolactin. Long-term hyperprolactinaemia may be associated with clinical sequeLae in some patients.
高催乳素血症在接受抗精神病药物治疗的患者中很常见。在英国哈利法克斯的一个社区心理健康信托机构中,对194名接受抗精神病药物治疗的精神分裂症和双相情感障碍患者进行了完整队列研究,在没有任何相关症状的情况下进行了常规催乳素筛查。该队列中38%的患者催乳素值高于正常上限,女性(52%)比男性(26%)更常见。21%的队列患者催乳素水平显著升高(>1000 mIU/l)。利培酮单药治疗的患者中有69%(n = 35)出现高催乳素血症,女性患者中这一比例为100%(n = 16),氨磺必利单药治疗的患者中这一比例为100%(n = 7)。目前英国没有常规进行催乳素筛查。这些数据表明,在对精神分裂症和双相情感障碍门诊无症状患者进行筛查时,可能会发现不同程度高催乳素血症的患病率。除了报告队列催乳素均值外,临床试验中此类分类数据的报告可能会对临床医生有所帮助。长期高催乳素血症在一些患者中可能与临床后遗症有关。