Noll Jennie G, Zeller Meg H, Trickett Penelope K, Putnam Frank W
Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229-3039, USA.
Pediatrics. 2007 Jul;120(1):e61-7. doi: 10.1542/peds.2006-3058.
Efforts are under way to articulate environmental, psychosocial, and biological conditions that may predispose the development and maintenance of obesity. There is increasing evidence that adverse childhood experiences such as childhood abuse may be implicated in the development of obesity. Given the dearth of prospective evidence for this link, the objective of this study was to track body mass across development (from childhood, through adolescence, and into young adulthood [ie, ages 6-27]) in a prospective, longitudinal study of abused and nonabused female subjects.
Height and weight were obtained for 84 female subjects with substantiated childhood sexual abuse and 89 demographically similar comparison female subjects at 6 points during development. Obesity status was examined at various stages during development, and body-mass growth trajectories were contrasted across the 2 groups. It was hypothesized that, in comparison with their nonabused peers, abused female subjects would be more likely to (1) manifest obesity by early adulthood and (2) manifest high-risk growth trajectories throughout development.
Obesity rates were not different across groups in childhood or adolescence. By young adulthood (ages 20-27), abused female subjects were significantly more likely to be obese (42.25%) than were comparison female subjects (28.40%). Hierarchical linear modeling growth-trajectory analyses indicated that abused female subjects, on average, acquired body mass at a significantly steeper rate from childhood through young adulthood than did comparison female subjects after controlling for minority status and parity.
Psychosocial difficulties (eg, depression) and psychobiological conditions (eg, hypothalamic-pituitary-adrenal axis dysregulation) that have been shown to be related to both childhood abuse and obesity may help to explain these results. The identification of high-risk growth trajectories may improve health outcomes for victims. Systematic study of the mechanistic pathways and mediating processes that would help to explain the connection between childhood sexual abuse and later obesity is encouraged.
人们正在努力阐明可能易导致肥胖发生和维持的环境、心理社会及生物学状况。越来越多的证据表明,诸如童年期受虐等不良童年经历可能与肥胖的发生有关。鉴于这一关联的前瞻性证据匮乏,本研究的目的是在一项针对受虐和未受虐女性受试者的前瞻性纵向研究中,追踪其从童年期、青春期直至青年期(即6至27岁)整个发育过程中的体重情况。
在发育过程中的6个时间点,对84名童年期遭受过性虐待且证据确凿的女性受试者以及89名在人口统计学特征上与之相似的对照女性受试者测量身高和体重。在发育的不同阶段检查肥胖状况,并对比两组的体重增长轨迹。研究假设,与未受虐的同龄人相比,受虐女性受试者更有可能:(1)在成年早期出现肥胖;(2)在整个发育过程中呈现高风险的生长轨迹。
在童年期或青春期,两组的肥胖率并无差异。到青年期(20至27岁),受虐女性受试者肥胖的可能性(42.25%)显著高于对照女性受试者(28.40%)。分层线性模型生长轨迹分析表明,在控制了少数族裔身份和生育状况后,受虐女性受试者从童年期到青年期平均获得体重的速度明显快于对照女性受试者。
已被证明与童年期受虐和肥胖均相关的心理社会困难(如抑郁)和心理生物学状况(如下丘脑 - 垂体 - 肾上腺轴失调)可能有助于解释这些结果。识别高风险生长轨迹可能会改善受害者的健康结局。鼓励对有助于解释童年期性虐待与后期肥胖之间联系的机制途径和中介过程进行系统研究。