Richardson Laura P, Davis Robert, Poulton Richie, McCauley Elizabeth, Moffitt Terrie E, Caspi Avshalom, Connell Frederick
Child Health Institute, Department of Pediatrics, University of Washington, Seattle 98115, USA.
Arch Pediatr Adolesc Med. 2003 Aug;157(8):739-45. doi: 10.1001/archpedi.157.8.739.
Prior studies have had conflicting results regarding the relationship between adolescent depression and adult obesity.
To test the hypothesis that depression in adolescence would increase the risk for obesity in early adulthood.
We used data from a longitudinal study of a birth cohort of children born between April 1, 1972, and March 31, 1973, in Dunedin, New Zealand (N = 1037). These data included regular diagnostic mental health interviews and height/weight measurements throughout childhood and adolescence. We performed logistic regression analyses to assess the relationship between major depression in early or late adolescence and the risk for obesity at 26 years of age.
Major depression occurred in 7% of the cohort during early adolescence (11, 13, and 15 years of age) and 27% during late adolescence (18 and 21 years of age). At 26 years of age, 12% of study members were obese. After adjusting for each individual's baseline body mass index (calculated as the weight in kilograms divided by the square of height in meters), depressed late adolescent girls were at a greater than 2-fold increased risk for obesity in adulthood compared with their nondepressed female peers (relative risk, 2.32; 95% confidence interval, 1.29-3.83). A dose-response relationship between the number of episodes of depression during adolescence and risk for adult obesity was also observed in female subjects. The association was not observed for late adolescent boys or for early adolescent boys or girls.
Depression in late adolescence is associated with later obesity, but only among girls. Future studies should address reasons for these age and sex differences and the potential for intervention to reduce the risk for adult obesity in depressed older adolescent girls.
先前的研究在青少年抑郁症与成人肥胖症之间的关系上得出了相互矛盾的结果。
检验青少年抑郁症会增加成年早期肥胖风险这一假设。
我们使用了对1972年4月1日至1973年3月31日在新西兰达尼丁出生的一组儿童（N = 1037）进行纵向研究的数据。这些数据包括整个儿童期和青少年期定期的心理健康诊断访谈以及身高/体重测量。我们进行了逻辑回归分析，以评估青少年早期或晚期的重度抑郁症与26岁时肥胖风险之间的关系。
在青少年早期（11、13和15岁），该队列中有7%的人患重度抑郁症，在青少年晚期（18和21岁），这一比例为27%。在26岁时，12%的研究对象肥胖。在调整了每个人的基线体重指数（以千克为单位的体重除以以米为单位的身高的平方计算）后，与未患抑郁症的女性同龄人相比，患抑郁症的青少年晚期女孩成年后肥胖风险增加了两倍多（相对风险，2.32；95%置信区间，1.29 - 3.83）。在女性受试者中也观察到青少年期抑郁症发作次数与成年肥胖风险之间存在剂量反应关系。在青少年晚期男孩或青少年早期男孩及女孩中未观察到这种关联。
青少年晚期的抑郁症与后期肥胖有关，但仅在女孩中如此。未来的研究应探讨这些年龄和性别差异的原因以及通过干预降低患抑郁症的大龄青少年女孩成年肥胖风险的可能性。
