Gürkan N, Terzioglu T, Tezelman S, Sasmaz O
Department of General Surgery, Istanbul Medical Faculty, Istanbul University, Turkey.
Br J Surg. 1991 Nov;78(11):1348-51. doi: 10.1002/bjs.1800781126.
Between 1979 and 1990 transhiatal oesophagectomy and reconstruction with stomach was performed in 148 patients with carcinoma of the oesophagus. Ninety-seven patients were men and 51 were women; ages ranged from 21 to 88 years with a mean of 57.4 years. Dysphagia and weight loss were the usual clinical symptoms. The mean duration of symptoms was 14 weeks. Squamous cell carcinoma was present in 129 patients (87.2 per cent), 18 patients (12.2 per cent) had adenocarcinoma, and one had lymphoma (0.7 per cent). In two-thirds of the patients tumours were located in the middle thoracic (50 of 148 patients) or distal thoracic oesophagus (59 of 148 patients). Three-quarters of the patients had tumours determined as stage III. The mean length of hospital stay after operation was 12.8 days. Anastomotic leakage occurred in 15 cases (10.1 per cent). Pulmonary complications other than pneumothorax were observed in 36 cases (24.3 per cent). The 30-day postoperative mortality rate was 8.1 per cent (12 of 148 patients). Respiratory insufficiency was observed as the major cause of death (six of 12 patients). Mediastinitis due to necrosis of the transposed stomach in the mediastinum was the cause of death in three cases. Two-year actuarial survival rates in patients with cervical, upper, middle and lower thoracic tumours were 20, 22, 26 and 30 per cent respectively. Transhiatal oesophagectomy is safe and offers limited morbidity and mortality, although pulmonary complications and anastomotic leakage in the early postoperative period still pose a significant risk, especially for elderly patients in poor condition.
1979年至1990年间,对148例食管癌患者实施了经胸食管切除术并以胃进行重建。其中男性97例,女性51例;年龄范围为21岁至88岁,平均年龄为57.4岁。吞咽困难和体重减轻是常见的临床症状。症状的平均持续时间为14周。129例患者(87.2%)为鳞状细胞癌,18例患者(12.2%)为腺癌,1例为淋巴瘤(0.7%)。三分之二的患者肿瘤位于胸段中段(148例患者中的50例)或胸段下段食管(148例患者中的59例)。四分之三的患者肿瘤被判定为III期。术后平均住院时间为12.8天。15例(10.1%)发生吻合口漏。除气胸外,36例(24.3%)观察到肺部并发症。术后30天死亡率为8.1%(148例患者中的12例)。观察到呼吸功能不全是主要死亡原因(12例患者中的6例)。纵隔内移植胃坏死导致的纵隔炎是3例患者的死亡原因。颈段、胸段上段、中段和下段肿瘤患者的两年精算生存率分别为20%、22%、26%和30%。经胸食管切除术是安全的,发病率和死亡率有限,尽管术后早期的肺部并发症和吻合口漏仍然构成重大风险,尤其是对于身体状况较差的老年患者。