病毒准种的快速进化：对疫苗和药物策略的影响
Rapid viral quasispecies evolution: implications for vaccine and drug strategies.
作者信息
Novella I S, Domingo E, Holland J J
机构信息
Department of Biology and Institute for Molecular Genetics, University of California, San Diego, La Jolla 92093-0016, USA.
出版信息
Mol Med Today. 1995 Aug;1(5):248-53. doi: 10.1016/s1357-4310(95)91551-6.
Abstract
High mutation rates occurring during replication allow RNA viruses to evolve rapidly and adapt continuously to new environments. This poses an enormous challenge to vaccine and drug development which, to be effective, must consider RNA virus variability and follow approaches that minimize the probability of escape or resistant mutants arising.
摘要
复制过程中出现的高突变率使RNA病毒能够快速进化，并不断适应新环境。这给疫苗和药物研发带来了巨大挑战，要想有效，就必须考虑RNA病毒的变异性，并采用能将逃逸或耐药突变体出现的概率降至最低的方法。
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