Domschke S, Domschke W, Rösch W, Konturek S J, Wünsch E, Demling L
Gastroenterology. 1976 Apr;70(4):533-6.
In seven healthy volunteers pure pancreatic juice was obtained by endoscopic cannulation of the papilla of Vater. Synthetic secretin was intravenously infused in doses doubled every 20 min. The volume of pancreatic juice was proportional to the log of the secretin dose. A significant rise (P less than 0.05) in pancreatic juice flow was elicited at a dose as low as 8.05 ng per kg per hr. Maximum flow rate approximating 250 mul per 5 min per kg of body weight was attained during infusion of 129 ng per kg per hr. At the same dose maximal bicarbonate outputs averaging 383 muEq per hr per kg of body weight were obtained, whereas bicarbonate ion concentration approached peak values (135 +/- 9 muEq per ml) at 32.2 ng per kg per hr. Bicarbonate concentrations showed a tendency to fall at supramaximal doses. The effect of increasing secretin doses on bicarbonate and cyclic AMP concentrations was remarkably similar (rs = 0.635, P less than 0.001) suggesting the participation of cyclic AMP in human pancreatic bicarbonate secretion.
在7名健康志愿者中，通过内镜下经十二指肠乳头插管获取纯胰液。以每20分钟剂量加倍的方式静脉输注合成促胰液素。胰液量与促胰液素剂量的对数成正比。每千克每小时低至8.05纳克的剂量即可引起胰液分泌显著增加（P<0.05）。在每千克每小时输注129纳克期间，达到了接近每5分钟每千克体重250微升的最大流速。在相同剂量下，每千克体重每小时平均最大碳酸氢盐输出量为383微当量，而在每千克每小时32.2纳克时，碳酸氢根离子浓度接近峰值（135±9微当量/毫升）。在超最大剂量时，碳酸氢盐浓度呈下降趋势。促胰液素剂量增加对碳酸氢盐和环磷酸腺苷浓度的影响非常相似（rs=0.635，P<0.001），提示环磷酸腺苷参与人体胰腺碳酸氢盐分泌。
