Weintraub Michael I, Khoury André, Cole Steven P
Department of Neurology and Medicine, New York Medical College, Valhalla, New York, USA.
J Neuroimaging. 2007 Jul;17(3):241-5. doi: 10.1111/j.1552-6569.2007.00118.x.
The recent use of high and ultra-high magnetic field (MF) systems (3.0 T and above) have raised concerns about biologic effects and safety. Sensory symptoms (magnetophosphenes, dizziness/vertigo, headaches, metallic taste, pain changes, and cognitive effects) have been reported. We monitored 1023 consecutive outpatients undergoing MRI after recent introduction of a 3 T MR unit in our community.
METHODS/DESIGN: Observational study utilizing a pretest and posttest symptom rating scale (0-10) questionnaire presented to subjects undergoing MRI at three different facilities with five MRI machines, specifically a 3 T (Philips), three units with 1.5 T (GE, GE, Philips), and one 0.6 T (Fonar) unit to record symptoms before and after study.
147 subjects (14%) experienced either new (N= 69; 6.7%) or changes (N= 78; 8%) in symptoms. New onset symptoms occurred predominantly with 3 T and female preponderance (75%) [P= .002]. Vertigo/dizziness (N= 28, 5.6%) [P= .001], headache (N= 8), spine pain (N= 11) occurred more frequently on 3 T, whereas magnetophosphenes (N= 8) and metallic mouth symptoms (N= 4) occurred principally in 1.5 T. Seventy-eight subjects (8%) experienced pain symptoms upward arrow downward arrow with 75% occurring with 1.5 T. Females were 60%. Forty-three percent of individuals had brain MRIs. Symptoms of vertigo/dizziness, headaches, and magnetophosphenes were more commonly seen in individuals undergoing brain MRIs but other body sites were also represented.
Although no harmful effects were reported in 1023 cases, an unexpected high rate of 14% of individuals experienced sensory stimulation in both 3 T and 1.5 T units. Females appear to be more magnetically sensitive.
近期高场强和超高场强（MF）系统（3.0 T及以上）的使用引发了对生物效应和安全性的担忧。已有感觉症状（磁幻视、头晕/眩晕、头痛、金属味、疼痛变化和认知效应）的相关报道。在我们社区最近引入一台3 T磁共振成像（MR）设备后，我们对1023例连续接受MRI检查的门诊患者进行了监测。
方法/设计：采用观察性研究，利用预先测试和测试后症状评分量表（0 - 10）问卷，向在三个不同设施的五台MRI机器上接受MRI检查的受试者发放问卷，具体为一台3 T（飞利浦）、三台1.5 T（通用电气、通用电气、飞利浦）和一台0.6 T（Fonar）设备，以记录研究前后的症状。
147名受试者（14%）出现了新症状（n = 69；6.7%）或症状变化（n = 78；8%）。新出现的症状主要发生在3 T设备上，且女性占优势（75%）[P = 0.002]。眩晕/头晕（n = 28，5.6%）[P = 0.001]、头痛（n = 8）、脊柱疼痛（n = 11）在3 T设备上更频繁出现，而磁幻视（n = 8）和金属味症状（n = 4）主要出现在1.5 T设备上。78名受试者（8%）出现疼痛症状加重或减轻，其中75%发生在1.5 T设备上。女性占60%。43%的个体进行了脑部MRI检查。眩晕/头晕、头痛和磁幻视症状在接受脑部MRI检查的个体中更常见，但其他身体部位也有出现。
尽管在1023例病例中未报告有害影响，但在3 T和1.5 T设备中，意外有14%的个体经历了感觉刺激。女性似乎对磁场更敏感。
