Gilabert-Estellés J, Ramón L A, España F, Gilabert J, Vila V, Réganon E, Castelló R, Chirivella M, Estellés A
Gynecology Service, Hospital Arnau de Vilanova, Valencia, Spain.
Hum Reprod. 2007 Aug;22(8):2120-7. doi: 10.1093/humrep/dem149. Epub 2007 Jul 3.
Endometriosis is a highly prevalent, benign disease in which the angiogenic, fibrinolytic and metalloproteinase (MMP) systems may be implicated. The objective of this study is to analyse mRNA expression and protein levels of several angiogenic factors and to correlate them with several components of the fibrinolytic and MMP systems in samples from 71 women with endometriosis and 50 controls.
Eutopic endometrium showed higher mRNA expression of vascular endothelial growth factor (VEGF) in patients than in controls. However, ovarian endometrioma had lower VEGF mRNA levels than did the eutopic endometrium of patients. Similar results were obtained for VEGF protein levels. On the other hand, a significant increase in thrombospondin-1 (TSP-1) levels was observed in ovarian endometrioma than in eutopic endometrium. The peritoneal fluid from women with endometriosis showed a significant increase in VEGF, urokinase-type plasminogen activator (uPA) and MMP-3 levels than that of controls. A significant correlation was observed between the levels of VEGF and uPA in endometrium and in peritoneal fluid.
Endometrium and peritoneal fluid from women with endometriosis have increased levels of VEGF, uPA and MMP-3 levels. Therefore, the development of endometriotic implants at ectopic sites may be facilitated, promoting the progress of the endometriosis.
子宫内膜异位症是一种高度常见的良性疾病，血管生成、纤维蛋白溶解和金属蛋白酶（MMP）系统可能与之相关。本研究的目的是分析71例子宫内膜异位症患者和50例对照样本中几种血管生成因子的mRNA表达和蛋白水平，并将它们与纤维蛋白溶解和MMP系统的几个成分进行关联分析。
异位内膜显示患者的血管内皮生长因子（VEGF）mRNA表达高于对照组。然而，卵巢子宫内膜异位囊肿的VEGF mRNA水平低于患者的异位内膜。VEGF蛋白水平也得到了类似结果。另一方面，观察到卵巢子宫内膜异位囊肿中的血小板反应蛋白-1（TSP-1）水平比异位内膜显著升高。子宫内膜异位症患者的腹腔液中VEGF、尿激酶型纤溶酶原激活物（uPA）和MMP-3水平比对照组显著升高。在子宫内膜和腹腔液中，VEGF和uPA水平之间观察到显著相关性。
子宫内膜异位症患者的子宫内膜和腹腔液中VEGF、uPA和MMP-3水平升高。因此，异位部位子宫内膜异位种植体的形成可能会得到促进，从而推动子宫内膜异位症的进展。
