Asherson Ronald A, Spargo Cathy, Gómez-Puerta Jose A
Division of Immunology, School of Pathology, University of the Witwatersrand School of Medicine, Johannesburg, South Africa.
Clin Rheumatol. 2008 Feb;27(2):245-8. doi: 10.1007/s10067-007-0683-1. Epub 2007 Jul 3.
A patient who developed thrombocytopenia and hypertension accompanied by high levels of antiphospholipid antibodies and abnormal liver function tests in the absence of a hemolytic anemia necessitating termination of pregnancy developed bilateral lower limb thromboses accompanied by painful maculo papular lesions on the palms of both hands a few days after ending the pregnancy. She was then also found to have a prothrombin gene G20210A mutation. She was treated with anticoagulation therapy, but her postpartum course was further complicated by pulmonary embolus. A Greenfield filter was inserted into the inferior vena cava. On low molecular weight heparin, her next pregnancy was uneventful and without any complications.