Krempf M, Ranganatan S, Ritz P, Garnier J M, Charbonnel B
Department of Metabolic Diseases, Hotel Dieu, Nantes, France.
Eur J Clin Pharmacol. 1991;41(5):411-5. doi: 10.1007/BF00626361.
The effect of 7-days of nifedipine treatment on insulin secretion has been analyzed in hypertensive patients with non-insulin-dependent mellitus (NIDDM). Pancreatic beta-cell function was assessed as insulin release following stimulation with arginine after potentiation by hyperglycaemia. Two groups of 5 patients with NIDDM (fasting blood glucose 139.2 mg.dl-1), on the same controlled diet, were compared; one was treated with nifedipine 30 mg per d and the other was the control. The mean blood pressure in the nifedipine group decreased (110 vs 102 mm Hg). Fasting blood glucose and basal plasma insulin were not affected by nifedipine. The acute insulin response (AIR) to 5 g arginine after potentiation by hyperglycaemia (clamped at 240 and 350 mg/dl for 30 min) was significantly (P less than 0.05) decreased, as well as the potentiation slope (line relating AIR and plasma glucose level) in those patients, and were unchanged in the control group. Thus, nifedipine may impair insulin secretion at high glucose levels in patients with NiDDM.
已对非胰岛素依赖型糖尿病（NIDDM）高血压患者进行了硝苯地平治疗7天对胰岛素分泌影响的分析。通过高血糖增强后，用精氨酸刺激后的胰岛素释放来评估胰腺β细胞功能。比较了两组各5名NIDDM患者（空腹血糖139.2mg·dl⁻¹），他们采用相同的控制饮食；一组每日服用30mg硝苯地平，另一组为对照组。硝苯地平组的平均血压下降（110对102mmHg）。空腹血糖和基础血浆胰岛素不受硝苯地平影响。高血糖增强后（钳制在240和350mg/dl 30分钟）对5g精氨酸的急性胰岛素反应（AIR）显著降低（P<0.05），这些患者的增强斜率（AIR与血浆葡萄糖水平的关系线）也降低，而对照组无变化。因此，硝苯地平可能损害NIDDM患者在高血糖水平时的胰岛素分泌。
