Tentorio A, Ghilardi G, Pedroncelli A, Benco R, Stroppa S, Adib S, Gianola D, Pagani G
Department of Endocrinology, United Hospitals of Bergamo, Italy.
Eur J Clin Pharmacol. 1989;36(3):311-3. doi: 10.1007/BF00558165.
The effect of nifedipine 40 mg.day-1 for 3 months on glucose tolerance, insulin and C-peptide secretion after an oral glucose tolerance test (OGTT), intra-venous glucose tolerance test (IVGTT) and glucagon stimulatory test, has been studied in 8 moderately hypertensive women suffering from non-insulin dependent diabetes mellitus (NIDDM). No significant variation in glucose metabolism was noted after nifedipine treatment, except for a slight improvement in insulin secretion after OGTT at the end of the study. There was an increase in cholesterol as a collateral effect.
对8名患有非胰岛素依赖型糖尿病（NIDDM）的中度高血压女性，研究了硝苯地平40毫克/天，持续3个月，对口服葡萄糖耐量试验（OGTT）、静脉葡萄糖耐量试验（IVGTT）和胰高血糖素刺激试验后葡萄糖耐量、胰岛素及C肽分泌的影响。硝苯地平治疗后，除研究结束时OGTT后胰岛素分泌略有改善外，未观察到葡萄糖代谢有显著变化。作为附带影响，胆固醇有所升高。
