Wang Fen, Shen Shou-rong, Zhou Jian-dang, Xu Can-xia
Department of Gastroenterology, Third Xiangya Hospital, Central South University, Changsha 410013, China.
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2007 Jun;32(3):447-50.
To examine the infection and bacteria resistance of Helicobacter pylori (H.pylori) to clarithromycin and furazolidone,to determine whether the antibiotic resistance is primary or secondary, and to decide if a new H.pylori infection plays a role in eradication failures.
Twenty one H.pylori had been isolated from human biopsy specimens, and antimicrobial susceptibility testing was performed. DNA fingerprints were generated using random amplification polymorphic DNA (RAPD) to determine the identity of H.pylori before and after the eradication therapy.
Eight bacteria resisted against clarithromycin, and one against furazolidone, with the resistant rates 38.1% and 4.8% respectively. The number of primary antibiotic resistance, secondary resistance and new infection was 1 for each.
Resistance to clarithromycin is more common compared with that to furazolidone. Development of primary and secondary resistance to clarithromycin occurs as a rule in eradication failures. New H.pylori infection plays a role in eradication failures.
检测幽门螺杆菌（H.pylori）对克拉霉素和呋喃唑酮的感染情况及细菌耐药性，确定抗生素耐药是原发性还是继发性，并判断新的H.pylori感染是否在根除失败中起作用。
从人体活检标本中分离出21株H.pylori，并进行药敏试验。使用随机扩增多态性DNA（RAPD）生成DNA指纹图谱，以确定根除治疗前后H.pylori的同一性。
8株细菌对克拉霉素耐药，1株对呋喃唑酮耐药，耐药率分别为38.1%和4.8%。原发性抗生素耐药、继发性耐药和新感染的数量均为1例。
与呋喃唑酮相比，对克拉霉素的耐药更常见。在根除失败中，通常会出现对克拉霉素的原发性和继发性耐药。新的H.pylori感染在根除失败中起作用。
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