Ellem Stuart J, Risbridger Gail P
Centre for Urological Research, Monash Institute of Medical Research, Monash University, 27-31 Wright Street, Clayton, Victoria, 3168, Australia.
Nat Rev Cancer. 2007 Aug;7(8):621-7. doi: 10.1038/nrc2174. Epub 2007 Jul 5.
Prostate cancer is the most commonly diagnosed cancer and the second most common cause of cancer-related death in men, and benign prostatic hyperplasia is the most common benign condition known to occur in ageing men. Oestrogen has been implicated in the development of prostate cancer, and offers a promising new avenue for treatment. Despite this, the role of oestrogens in the prostate is complex. This Perspective presents a rationale for a targeted approach for the treatment of prostate disease through the use of selective oestrogen-receptor modulators in conjunction with contemporary androgen-ablation therapy.
前列腺癌是男性中最常被诊断出的癌症，也是癌症相关死亡的第二大常见原因，而良性前列腺增生是已知在老年男性中最常见的良性病症。雌激素与前列腺癌的发生有关，并为治疗提供了一个有前景的新途径。尽管如此，雌激素在前列腺中的作用是复杂的。本观点阐述了通过使用选择性雌激素受体调节剂结合当代雄激素剥夺疗法来靶向治疗前列腺疾病的基本原理。
