Pulver A E, Liang K Y
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Genet Epidemiol. 1991;8(5):339-50. doi: 10.1002/gepi.1370080506.
In this report we apply methods outlined in the companion paper [Liang, Genet Epidemiol 8:329-338, 1991] to study the association between proband age at onset and familial risk among first-degree relatives of 374 schizophrenic probands. The analyses take into consideration the potential problems of censoring and correlation of age at onset within families. All analyses were done by gender of the proband; age at onset was dichotomized. The results of the analyses of the male probands suggest that there is an increased risk of schizophrenia among the relatives of male probands who have an onset prior to age 17 when compared to relatives of male probands who have an onset later than 16. We did not find an association between age at onset and familial risk among the female probands, but this may be due to the smaller number of female probands and the lower power associated with the analyses.
在本报告中，我们应用了配套论文[梁，《遗传流行病学》8:329 - 338，1991]中概述的方法，来研究374名精神分裂症先证者的一级亲属中，先证者发病年龄与家族风险之间的关联。分析考虑了发病年龄在家庭内部的潜在截尾问题和相关性。所有分析均按先证者性别进行；发病年龄被二分法分类。对男性先证者的分析结果表明，与发病年龄晚于16岁的男性先证者的亲属相比，发病年龄在17岁之前的男性先证者的亲属患精神分裂症的风险增加。我们未发现女性先证者的发病年龄与家族风险之间存在关联，但这可能是由于女性先证者数量较少以及分析的检验效能较低所致。
