老年及预后较差的高级别胶质瘤患者：大分割放疗
Elderly and poor prognosis patients with high grade glioma: hypofractionated radiotherapy.
作者信息
Donato V, Monaco A, Rollo A, Messineo D, Santuari L, Castrichino A, Caiazzo R, Salvati M, Delfini R, Banelli E
机构信息
Department of Radiology, Policlinico Umberto I, University La Sapienza, Rome, Italy.
出版信息
Clin Ter. 2007 May-Jun;158(3):227-30.
AIM
To evaluate efficacy of short-course radiotherapy in elderly and/or poor performance status patients with high grade glioma.
MATERIALS AND METHODS
Twenty-one patients with high grade astrocytoma were selected in our Institute to receive hypofractionated radiotherapy. We considered two radiotherapy treatment arms: in arm I there were 22 patients treated with 60 Gy in 30 fractions at 5 fractions per week; in arm 2 there were 21 patients who received hypofractionated radiotherapy course of 30 Gy in 10 fractions at 5 fractions per week.
RESULTS
In arm1 the median survival time was 8.2 months and the 1 year overall survival was 36%; in arm 2 the estimated median survival was 6.2 months and the 1 year overall survival was 23%. Treatment was without acute toxicity.
CONCLUSIONS
In our experience, hypofractionated radiotherapy seems to be a reasonable treatment option for poor prognosis patients with high grade astrocytoma. It is well tolerated and can reduce the overall treatment time without negative effects on survival compared with conventional fractionation.
目的
评估短程放疗对老年和/或身体状况较差的高级别胶质瘤患者的疗效。
材料与方法
我院选取21例高级别星形细胞瘤患者接受大分割放疗。我们考虑了两个放疗治疗组：第一组有22例患者，每周5次，分30次给予60 Gy照射；第二组有21例患者，每周5次，分10次给予30 Gy的大分割放疗疗程。
结果
第一组的中位生存时间为8.2个月，1年总生存率为36%；第二组的估计中位生存时间为6.2个月，1年总生存率为23%。治疗无急性毒性。
结论
根据我们的经验，大分割放疗似乎是预后较差的高级别星形细胞瘤患者的合理治疗选择。与传统分割放疗相比，它耐受性良好，可以缩短总治疗时间，且对生存无负面影响。
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