Ghosh A K, Sen S, Sharma A, Talukder G
Department of Botany, University of Calcutta, India.
Food Chem Toxicol. 1991 Nov;29(11):777-9. doi: 10.1016/0278-6915(91)90187-c.
The effect of chlorophyllin (1.5 mg/kg body weight) on the clastogenicity of mercuric chloride (HgCl2) was studied in vivo in mouse bone marrow cells. HgCl2 (3.0, 6.0 and 12.0 mg/kg body weight) administered by gavage induced chromosomal aberrations at frequencies directly proportional to the dose. Chlorophyllin was not clastogenic, and significantly reduced the mitotic index when given alone. Chlorophyllin administered simultaneously with HgCl2 significantly reduced the frequencies of chromosomal aberrations in a dose-dependent manner. When given simultaneously with the lowest HgCl2 concentration tested (3.0 mg/kg body weight), chlorophyllin provided total protection. A lower degree of protection was given by chlorophyllin administered 2 hr before HgCl2. The data demonstrate the potential of green plant components to modify the genotoxic activity of HgCl2 when administered orally.
研究了叶绿酸（1.5毫克/千克体重）对氯化汞（HgCl₂）致断裂作用的影响，实验在小鼠骨髓细胞体内进行。通过灌胃给予氯化汞（3.0、6.0和12.0毫克/千克体重），诱导染色体畸变的频率与剂量成正比。叶绿酸不具有致断裂作用，单独给予时可显著降低有丝分裂指数。与氯化汞同时给予时，叶绿酸以剂量依赖的方式显著降低染色体畸变频率。当与测试的最低氯化汞浓度（3.0毫克/千克体重）同时给予时，叶绿酸提供了完全保护。在氯化汞给药前2小时给予叶绿酸，其保护程度较低。数据表明，口服绿色植物成分有改变氯化汞遗传毒性活性的潜力。
