Jirikowski G F, Ramalho-Ortigao F J, Caldwell J D
Abt. Anatomie und Zellbiologie, Universität Ulm, Germany.
Horm Metab Res. 1991 Oct;23(10):476-80. doi: 10.1055/s-2007-1003733.
We used in situ hybridization and immunocytochemistry to investigate a possible coexistence of vasopressin and oxytocin in hypothalamic neurons of parturient rats. We found that a fraction of magnocellular neurons in the paraventricular and supraoptic nuclei contained immunostaining for both peptides as well as oxytocin and vasopressin mRNA hybridization. Colocalization of immunoreactive vasopressin and oxytocin could be observed in some of the Herring bodies in the median eminence and the posterior lobe. No coexistence of vasopressin and oxytocin was found in pregnant or in lactating animals, indicating that the observed coexistence is transitory, perhaps mediated through changing hormonal conditions peri partum.
我们采用原位杂交和免疫细胞化学方法，研究分娩期大鼠下丘脑神经元中血管加压素和催产素可能的共存情况。我们发现，室旁核和视上核中的一部分大细胞神经元含有两种肽的免疫染色以及催产素和血管加压素mRNA杂交信号。在正中隆起和后叶的一些赫林体中可观察到免疫反应性血管加压素和催产素的共定位。在怀孕或哺乳的动物中未发现血管加压素和催产素共存，这表明观察到的共存是短暂的，可能是由围产期激素条件的变化介导的。
