Guzek J W, Juszczak M
Exp Clin Endocrinol. 1987 Mar;89(1):97-104. doi: 10.1055/s-0029-1210633.
Pinealectomized (PX), sham-operated and non operated control rats were injected intraperitoneally (i.p.), once daily at 8.00 over five days, with: (a) 0.9% sodium chloride, (b) propranolol hydrochloride in a dose of 10 mg/kg (= 0.1 ml solution per 100 g b.w.). Three hours following the last injection the animals were decapitated and the content of vasopressin and oxytocin was bioassayed in the hypothalamus and neurointermediate lobe. PX was followed by known decrease of both vasopressin and oxytocin in the hypothalamus and neurohypophysis. In rats not-PX propranolol did not change the vasopressin and oxytocin content in the hypothalamus and neurointermediate lobe. In PX-rats, treatment with propranolol resulted in a distinct increase of the vasopressin in the neurohypophysis. It may be therefore supposed that the beta-adrenergic transmission is in some way involved in the regulatory mechanisms of pineal-neurohypophysial functional relationship.
对松果体切除（PX）、假手术和未手术的对照大鼠，在五天内每天上午8点经腹腔注射（i.p.）：（a）0.9%氯化钠，（b）剂量为10mg/kg的盐酸普萘洛尔（相当于每100g体重注射0.1ml溶液）。末次注射后三小时，将动物断头，对下丘脑和神经中间叶中的血管加压素和催产素含量进行生物测定。松果体切除后，下丘脑和神经垂体中的血管加压素和催产素均出现已知的减少。在未行松果体切除的大鼠中，普萘洛尔不改变下丘脑和神经中间叶中血管加压素和催产素的含量。在松果体切除的大鼠中，用普萘洛尔治疗导致神经垂体中血管加压素明显增加。因此可以推测，β-肾上腺素能传递在某种程度上参与了松果体-神经垂体功能关系的调节机制。
